Welcome to 201 River Rd poised on the Sampit River with sweeping views of Winyah Bay. This stately waterfront residence has been reimagined as a boutique inn~style retreat offering extraordinary capacity and flexibility in Historic Georgetown. Classic Southern architecture, deep columned rear porches, and an expansive riverfront lawn create a refined coastal setting for gatherings, retreats, and unforgettable stays. Inside, the main house spans just under 5,000 square feet with an open brick-floored living hall anchored by a striking masonry fireplace, built-in cabinetry, and walls of glass framing boats and marsh wildlife. The main level hosts five bedrooms and four full baths, including suites connected by a Jack-and-Jill bath that work beautifully for groups while still allowing privacy. Upstairs, four additional bedroom suites each enjoy their own full bath and open to a broad balcony overlooking Hazzard Marina and the sparkling bay, creating a true inn-like experience for guests. In total, the main home offers nine bedrooms and eight full baths, thoughtfully arranged to support multi-suite living, intimate events, or a thriving bed and breakfast concept. A separate but attached guest suite lives like a private studio apartment, complete with its own kitchen, full bath, and private entrance, ideal for an on-site host, extended-stay visitors, or an additional revenue stream. Beyond the home, a deep riverfront porch with multiple seating areas and ceiling fans invites morning coffee and sunset cocktails, while Front St Harborwalk, chef-owned restaurants, boutiques, museums, and marinas are just moments away in Historic Downtown Georgetown. Arrange a private showing to explore the many ways 201 River Road can support a distinctive boutique inn, flexible multi-use retreat, or an exceptional coastal residence. Call the listing agent today for a showing!