Own a piece of Cleveland history in the heart of Little Italy. Located at 2078 Murray Hill Road, this historic mixed-use building presents a rare opportunity to create something special in one of Cleveland's most celebrated cultural districts. Offering approximately 1,660 square feet above grade, plus two additional lower-level spaces, this property is ready for your vision. The street-level storefront commands attention with a large display window and its original vintage pressed-tin ceiling, creating an inviting setting for a boutique, art gallery, artist's studio, café concept, professional office, or other creative venture. Upstairs, you'll find two bedrooms and one-and-a-half baths, creating an ideal live/work environment or private residence above your business. This is a rare blank canvas for a complete custom restoration, allowing the next owner to preserve the building's historic character while making it their own. The spacious rear yard offers exciting potential for outdoor retail, an artist courtyard, sculpture garden, outdoor dining, or entertaining space. Two lower-level spaces provide additional flexibility for storage, workshops, studio space, wine cellar, or future expansion. Just steps from Little Italy's renowned restaurants, galleries, cafés, bakeries, specialty shops, and annual festivals, and minutes from University Circle, Case Western Reserve University, Cleveland Clinic, University Hospitals, the Cleveland Museum of Art, and the RTA Red Line, this property offers an exceptional opportunity in one of Northeast Ohio's most vibrant and walkable neighborhoods. Opportunities to acquire and customize a historic mixed-use building on Murray Hill Road are increasingly rare. Bring your vision and restore one of Little Italy's iconic mixed-use buildings into a signature destination in one of Cleveland's most sought-after cultural districts.