Welcome to 4421 Laclede Avenue, located in Laclede Place. This charming, semi-private block of Laclede Avenue is distinguished by its beautifully landscaped boulevard, mature trees, and timeless architectural character. This exceptional home is being offered for the first time in 45 years and has been lovingly maintained and thoughtfully updated throughout. Step into the stunning foyer, where original millwork and a beautiful fireplace create an unforgettable first impression. Separated by pocket doors, the gracious living room features its own fireplace, while the formal dining room offers yet another fireplace. The chef's kitchen is designed for both everyday living and entertaining, featuring custom cabinetry, stainless steel appliances, and an oversized center island. Just beyond, the expansive great room is filled with natural light from an abundance of windows, creating a bright and inviting gathering space. The second floor is anchored by the luxurious primary suite, complete with a fireplace and a spa-inspired bath featuring dual vanities and a separate walk-in shower. The second bedroom has a wall of custom built-in bookcases and its own fireplace; a third bedroom and an additional full bath complete the level. The third floor offers even more flexibility with two additional bedrooms and another full bath, providing ample space for family, guests, or a home office. The finished lower level, complete with egress windows and abundant natural light, offers flexible living space perfect for a home office, playroom, or recreation area and includes a convenient half bath and additional storage space. Find your own private oasis in the backyard, thoughtfully designed for both relaxation and entertaining. Enjoy a charming screened-in room, a spacious deck perfect for grilling and outdoor dining, and a covered hot tub for year-round enjoyment. The beautifully curated grounds feature an impressive variety of plantings—from fresh vegetables and lush landscaping to your very own banana plants—creating a truly unique outdoor retreat. A rare blend of historic elegance and peaceful surroundings, this exceptional location places you just moments from the vibrant shops, restaurants, and cultural attractions of the Central West End while maintaining a quiet, neighborhood feel. Close to Barnes Jewish, WashU Med School, The Cortex and Saint Louis University.