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381 SE 5th Avenue, 
Melrose, FL 32666

$579,000

4

Beds

2

Baths

2,037

Sq Ft

Single Family

Virtual Tour

Active

Listed by

Julia Ariet

, 

Angela Rupp

Keller Williams Gainesville Realty Partners

Last updated:

February 17, 2026, 01:11 PM

MLS#

GC535446

Source:

MFRMLS

About This Home

381 SE 5th Avenue

Offering over 2,000 square feet of living space, this 4-bedroom, 2-bath home is perfectly positioned on a nearly 2/3-acre lot on the canal giving direct access to Lake Santa Fe in Melrose, Florida. Enjoy a lake lifestyle with beautiful water views on three sides of the property, mature palm trees, and direct access to peaceful canal scenery. A large screened-in back patio and expansive deck create ideal spaces for relaxing, entertaining, or enjoying Florida’s year-round outdoor living. Recent updates include flooring, bathrooms, windows, and kitchen appliances. Additional highlights include a covered carport with extra storage, a rebuilt bulkhead (2015), and a newer HVAC system (2023). Conveniently located just over 3 miles to grocery shopping and approximately 2 miles from Melrose Elementary and the historic district of Melrose. Fourth 'bedroom' was used as a guest room. It does not have a closet, but has handy closet storage available in the laundry room adjacent to it. Only 25 minutes to UF.

Home Facts

Single Family

2 Baths

4 Bedrooms

Built in 1986

Price Summary

579,000

$284 per Sq. Ft.

MLS #:

GC535446

Last Updated:

February 17, 2026, 01:11 PM

Added:

3 month(s) ago

Rooms & Interior

Bedrooms

Total Bedrooms:

4

Bathrooms

Total Bathrooms:

2

Full Bathrooms:

2

Interior

Living Area:

2,037 Sq. Ft.

Structure

Structure

Building Area:

2,783 Sq. Ft.

Year Built:

1986

Lot

Lot Size (Sq. Ft):

28,400

Finances & Disclosures

Finances

Price:

$579,000

Price per Sq. Ft:

$284 per Sq. Ft.

MLS Logo
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Contact an Agent

Yes, I would like more information. Please use and/or share my information with a Coldwell Banker ® affiliated agent to contact me about my real estate needs. By clicking Contact, I request to be contacted by phone or text message and consent to being contacted by automated means. I understand that my consent to receive calls or texts is not a condition of purchasing any property, goods, or services. Alternatively, I understand that I can access real estate services by email or I can contact the agent myself.

If a Coldwell Banker affiliated agent is not available in the area where I need assistance, I agree to be contacted by a real estate agent affiliated with another brand owned or licensed by Anywhere Real Estate (BHGRE®, CENTURY 21®, Corcoran®, ERA®, or Sotheby's International Realty®). I acknowledge that I have read and agree to the terms of use and privacy notice.