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643 Grand Avenue, 
South San Francisco, CA 94080

$1,248,000

3

Beds

4

Baths

1,630

Sq Ft

Single Family

Active

Listed by

Jill Penna

Christie'S International Real Estate Sereno

650-844-7373

Last updated:

August 29, 2026, 10:31 AM

MLS#

ML82059314

Source:

CRMLS

About This Home

643 Grand Avenue

Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

Home Facts

Single Family

4 Baths

3 Bedrooms

Built in 1895

Price Summary

1,248,000

$765 per Sq. Ft.

MLS #:

ML82059314

Last Updated:

August 29, 2026, 10:31 AM

Added:

2 day(s) ago

Rooms & Interior

Bedrooms

Total Bedrooms:

3

Bathrooms

Total Bathrooms:

4

Full Bathrooms:

4

Interior

Living Area:

1,630 Sq. Ft.

Structure

Structure

Building Area:

1,630 Sq. Ft.

Year Built:

1895

Lot

Lot Size (Sq. Ft):

3,497

Finances & Disclosures

Finances

Price:

$1,248,000

Price per Sq. Ft:

$765 per Sq. Ft.

Source:CRMLS
The information being provided by California Regional MLS (Southern California) is for the consumer's personal, non-commercial use and may not be used for any purpose other than to identify prospective properties consumer may be interested in purchasing. Any information relating to real estate for sale referenced on this web site comes from the Internet Data Exchange (IDX) program of the California Regional MLS (Southern California). Coldwell Banker Diamond is not a Multiple Listing Service (MLS), nor does it offer MLS access. This website is a service of Coldwell Banker Diamond, a broker participant of California Regional MLS (Southern California). This web site may reference real estate listing(s) held by a brokerage firm other than the broker and/or agent who owns this web site. The accuracy of all information, regardless of source, including but not limited to open house information, square footages and lot sizes, is deemed reliable but not guaranteed and should be personally verified through personal inspection by and/or with the appropriate professionals. The data contained herein is copyrighted by California Regional MLS (Southern California) and is protected by all applicable copyright laws. Any unauthorized dissemination of this information is in violation of copyright laws and is strictly prohibited. Copyright 2021 California Regional MLS (Southern California). All rights reserved.
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643 Grand Avenue
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Contact an Agent

Your message will be sent to a Coldwell Banker Agent

Yes, I would like more information. Please use and/or share my information with a Coldwell Banker ® affiliated agent to contact me about my real estate needs. By clicking Contact, I request to be contacted by phone or text message and consent to being contacted by automated means. I understand that my consent to receive calls or texts is not a condition of purchasing any property, goods, or services. Alternatively, I understand that I can access real estate services by email or I can contact the agent myself.

If a Coldwell Banker affiliated agent is not available in the area where I need assistance, I agree to be contacted by a real estate agent affiliated with another brand owned or licensed by Anywhere Real Estate (BHGRE®, CENTURY 21®, Corcoran®, ERA®, or Sotheby's International Realty®). I acknowledge that I have read and agree to the terms of use and privacy notice.